Cal thrives on affection from others, so he would probably isolate him to Siberian levels through various tactics, like winning over those who like him, forcing Cal to show his terrormonster hand, and so on. He's on Peridot though, so getting him left alone by his team would take a great feat. However, Cass has felt isolated in Peridot before so it isn't impossible. Just highly unlikely . . .

Echo, why are you on a justice bender? Why are you trying?